[HTML][HTML] Serum biomarkers and ultrasensitive biosensors for diagnosis of early-stage hepatocellular carcinoma

LDS Lapitan Jr, M Pietrzak, M Krawczyk… - Sensors and Actuators B …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) was the third leading cause of cancer-related death
globally in 2020. The treatment of the disease is complex, with a high possibility of disease …

Aptamer-based liquid biopsy

L Wu, Y Wang, L Zhu, Y Liu, T Wang, D Liu… - ACS applied bio …, 2020 - ACS Publications
Liquid biopsy allows noninvasive and real-time analysis of tumor-derived circulating targets
in body fluids, holding great value for cancer diagnosis, prognosis, personalized therapy, as …

High affinity truncated aptamers for ultra-sensitive colorimetric detection of bisphenol A with label-free aptasensor

M Jia, J Sha, Z Li, W Wang, H Zhang - Food chemistry, 2020 - Elsevier
The widespread exposure of bisphenol A (BPA) presents a significant risk to human health.
A rapid, ultra-sensitive and label-free colorimetric aptasensor using high affinity truncated …

Self-assembled DNA nanocentipede as multivalent drug carrier for targeted delivery

W Li, X Yang, L He, K Wang, Q Wang… - … applied materials & …, 2016 - ACS Publications
An idea drug carrier, with good binding affinity, selectivity, drug payload capacity, and
cellular internalized capability, will greatly improve the efficiency of target delivery. Herein a …

Recent advances in aptamer-based liquid biopsy

J Zhang, Y Huang, M Sun, S Wan… - ACS Applied Bio …, 2022 - ACS Publications
Liquid biopsy capable of noninvasive and real-time molecular profiling is considered as a
breakthrough technology, endowing an opportunity for precise diagnosis of individual …

Artificial antibody with site-enhanced multivalent aptamers for specific capture of circulating tumor cells

L Liu, K Yang, H Gao, X Li, Y Chen, L Zhang… - Analytical …, 2019 - ACS Publications
Isolation of circulating tumor cells (CTCs) from blood holds great potential to diagnose
cancers and discover therapeutic targets. Herein, we reported a novel kind of artificial …

A platform for primary tumor origin identification of circulating tumor cells via antibody cocktail-based in vivo capture and specific aptamer-based multicolor …

M Jia, Y Mao, C Wu, S Wang, H Zhang - Analytica Chimica Acta, 2019 - Elsevier
Circulating tumor cells (CTCs) are expected to serve as a blood-based biomarker in the
diagnosis of cancers at an early stage, providing an opportunity to increase the survival of …

Trends in the design and development of specific aptamers against peptides and proteins

M Tabarzad, M Jafari - The Protein Journal, 2016 - Springer
Aptamers are single stranded oligonucleotides, comparable to monoclonal antibodies
(mAbs) in selectivity and affinity and have significant strategic properties in design …

[HTML][HTML] A new theranostic system based on endoglin aptamer conjugated fluorescent silica nanoparticles

J Tan, N Yang, L Zhong, J Tan, Z Hu, Q Zhao… - Theranostics, 2017 - ncbi.nlm.nih.gov
Background: Tumor vessels can potentially serve as diagnostic, prognostic and therapeutic
targets for solid tumors. Fluorescent dyes are commonly used as biological indicators, while …

A fluorescent aptasensor for sensitive detection of human hepatocellular carcinoma SMMC-7721 cells based on graphene oxide

Q Xie, Y Tan, Q Guo, K Wang, B Yuan, J Wan… - Analytical …, 2014 - pubs.rsc.org
In this work, we reported a simple, rapid and sensitive fluorescence method for the direct
detection of cancer cells using a graphene oxide (GO)-based aptasensor. This method took …