Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of
solid tumours that plays a crucial role in shaping their progression. Many desmoplastic …

Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …

As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …

Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

The extracellular matrix (ECM) is a complex and dynamic meshwork of cross-linked proteins
that supports cell polarization and functions and tissue organization and homeostasis. Over …

Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk,
critically affecting metastasis and treatment resistance, remains elusive. Our results show …