The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

This survey reviews modern ideas on the structure and functions of mitochondrial and
cytosolic aconitase isoenzymes in eukaryotes. Cumulative experimental evidence about …

The pace of species extinction and deforestation has increased dramatically due to the
substantial increase in global environmental degradation. This trend is approaching the …

Here, we present FLiPPR, or FragPipe LiP (limited proteolysis) Processor, a tool that
facilitates the analysis of data from limited proteolysis mass spectrometry (LiP-MS) …

Life activities are supported by the intricate metabolic network that is fueled by nutrients.
Nutritional and genetic studies in model organisms have determined that dietary restriction …

Aging is a universal process of age-dependent physiological and functional declines that
are strongly associated with human diseases. Despite extensive studies of the molecular …

Limited proteolysis coupled to mass spectrometry (LiP-MS) has emerged as a powerful
proteomic tool for studying protein conformations. Since its introduction in 2014, LiP-MS has …

One of the planet's more understudied ecosystems is the deep biosphere, where organisms
can experience high hydrostatic pressures (30–110 MPa); yet, by current estimates, these …

The declining capacity of cells to maintain a functional proteome is a major driver of cellular
dysfunction and decreased fitness in aging. Here we assess the impact of aging on multiple …

Protein self-association is a widespread phenomenon that results in the formation of
multimeric protein structures with critical roles in cellular processes. Protein self-association …