Drug hypersensitivity may manifest ranging from milder skin reactions (eg, maculopapular
exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions …

Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a
foundation of an excess body burden of uric acid, manifested in part by hyperuricemia …

Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent
cause of severe cutaneous adverse reactions (SCAR), which include the drug …

Objective To compare the urate‐lowering efficacy and safety of febuxostat, allopurinol, and
placebo in a large group of subjects with hyperuricemia and gout, including persons with …

Objective Allopurinol is the most commonly used urate‐lowering therapy in gout. Allopurinol
hypersensitivity syndrome (AHS) is a rare but potentially fatal adverse event. Dosing …

BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
are rare severe cutaneous adverse reactions. OBJECTIVES: We sought to update …

The flavonoid family has been reported to possess a high potential for inhibition of xanthine
oxidase (XO). This study concerned the structural aspects of inhibitory activities and binding …

The purine analogue, allopurinol, has been in clinical use for more than 30 years as an
inhibitor of xanthine oxidase (XO) in the treatment of hyperuricemia and gout. As …

Objective Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …

Background Insufficient renal urate excretion and/or overproduction of uric acid (UA) are the
dominant causes of hyperuricemia. Baicalein (BAL) is widely distributed in dietary plants …