Cinnamic acid hybrids as anticancer agents: A mini‐review

LS Feng, JB Cheng, WQ Su, HZ Li, T Xiao… - Archiv der …, 2022 - Wiley Online Library
Cancer, as a long‐lasting and dramatic disease, affects almost one‐third of human beings
globally. Chemotherapeutics play an important role in cancer treatment, but multidrug …

Is dual inhibition of metalloenzymes HDAC-8 and MMP-2 a potential pharmacological target to combat hematological malignancies?

SA Amin, N Adhikari, T Jha - Pharmacological Research, 2017 - Elsevier
For the last three decades, metalloenzymes such as histone deacetylases (HDACs) and
matrix metalloproteinases (MMPs) have been identified in promoting solid as well as …

Guizhi Fuling Wan reduces autophagy of granulosa cell in rats with polycystic ovary syndrome via restoring the PI3K/AKT/mTOR signaling pathway

M Liu, H Zhu, Y Zhu, X Hu - Journal of Ethnopharmacology, 2021 - Elsevier
Abstract Ethnopharmacological relevance Guizhi Fuling Wan (GFW) is a traditional Chinese
medicine used to remove blood stasis and dissipate phlegm for treating gynecological …

Targets and mechanism used by cinnamaldehyde, the main active ingredient in cinnamon, in the treatment of breast cancer

Y Liu, T An, D Wan, B Yu, Y Fan, X Pei - Frontiers in Pharmacology, 2020 - frontiersin.org
Background: Breast cancer has become one of the most common malignant tumors in
women owing to its increasing incidence each year. Clinical studies have shown that …

[HTML][HTML] Synthesis of cinnamic acid ester derivatives with antiproliferative and antimetastatic activities on murine melanoma cells

JA do Vale, MP Rodrigues, ÂMA Lima… - Biomedicine & …, 2022 - Elsevier
Melanoma is the most aggressive skin cancer, and its incidence has continued to rise during
the past decades. Conventional treatments present severe side effects in cancer patients …

Pingchong Jiangni recipe through nerve growth factor/transient receptor potential vanilloid 1 signaling pathway to relieve pain in endometriosis model rats

D Chen, Y Ren, J Jin, S Liu, X Zhan, X Li… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Pingchong Jiangni recipe (PJR) is often used in
the treatment of endometriosis (EM). This formula has been clinically validated by the State …

Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry

M El-Gaby, YA Ammar, M IH El-Qaliei… - Egyptian Journal of …, 2020 - journals.ekb.eg
This review spotlights sulfonamides from different sides, including history, structure-activity
relationship, chemistry, methods of classification and up to date ways for their synthesis …

Cinnamon extracts, trans-cinnamaldehyde and trans-cinnamic acid inhibit HDAC 1 activity

H Koyu, H Istanbullu, SET Ozoglu, TK Temiz - Food & Function, 2024 - pubs.rsc.org
Histone deacetylase (HDAC) enzymes play a key role in cell function and are implicated in
several diseases such as inflammation, cancer, and neurodegeneration. Studies on natural …

Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential

S Ramos-Inza, A Henriquez-Figuereo, E Moreno… - Molecules, 2022 - mdpi.com
Currently, cancer, leishmaniasis and bacterial infections represent a serious public health
burden worldwide. Six cinnamyl and benzodioxyl derivatives incorporating selenium (Se) as …

Strawberry tree honey as a new potential functional food. Part 2: Strawberry tree honey increases ROS generation by suppressing Nrf2-ARE and NF-кB signaling …

S Afrin, TY Forbes-Hernández, D Cianciosi… - Journal of Functional …, 2019 - Elsevier
The aim of the present study was to evaluate the effects of Strawberry tree honey (STH) on
oxidative stress, metabolic phenotype, migration, invasion and epithelial-mesenchymal …