Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis
selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a …

Micro (mi) RNAs are small, highly conserved noncoding RNAs that control gene expression
post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein …

Cholangiocarcinoma (CCA) is an epithelial can-cer originating from the bile ducts with
features of cholangiocyte differentiation. 1 CCA is the second most common primary hepatic …

Abstract c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its
abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes …

The members of the Bcl-2 family are the central regulators of various cell death modalities.
Some of these proteins contribute to apoptosis, while others counteract this type of …

The development of selective inhibitors for discrete anti-apoptotic BCL-2 family proteins
implicated in pathologic cell survival remains a formidable but pressing challenge. Such …

Each day, the human body eliminates billions of unwanted cells by apoptotic suicide.
Apoptosis provides an important barrier against cancer; however, specific mutations enable …

Patients with inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease,
are at increased risk of developing colon cancer, confirming that chronic inflammation …

Cancer is a leading cause of premature human death and commands considerable
research attention. Apoptosis (type 1 programmed cell death) is critical in maintaining tissue …