Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

Neuromuscular junction (NMJ) formation requires agrin, a factor released from
motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin …

The mechanisms that govern synapse formation and elimination are fundamental to our
understanding of neural development and plasticity. The wiring of neural circuitry requires …

Congenital myasthenic syndromes (CMSs) are a group of inherited disorders of
neuromuscular transmission characterized by fatigable muscle weakness. One major …

The Abelson tyrosine kinases were initially identified as drivers of leukemia in mice and
humans. The Abl family kinases Abl1 and Abl2 regulate diverse cellular processes during …

The Abl-family non-receptor tyrosine kinases are essential regulators of the cytoskeleton.
They transduce diverse extracellular cues into cytoskeletal rearrangements that have …

The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between
motoneuron and skeletal muscle, is characterized by a protracted postnatal period of …

The vertebrate neuromuscular junction (NMJ) remains the best‐studied model for
understanding the mechanisms involved in synaptogenesis, due to its relatively large size …

Agrin, a motoneuron-derived factor, and the muscle-specific receptor tyrosine kinase (MuSK)
are essential for the acetylcholine receptor (AChR) clustering at the postjunctional …