Significance: Blood forming, hematopoietic stem cells (HSCs) mostly reside in the bone
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …

Reactive oxygen species (ROS) are a heterogeneous group of molecules that are generated
by mature myeloid cells during innate immune responses, and are also implicated in normal …

Abstract Glutathione S‑transferase Pi (GSTP1) is an isozyme encoded by the GST pi gene
that plays an important regulatory role in detoxification, anti‑oxidative damage, and the …

Glutathione S-transferase P is abundantly expressed in some mammalian tissues,
particularly those associated with malignancies. While the enzyme can catalyze thioether …

Beyond the disorders recognized as mitochondrial diseases, abnormalities in function
and/or ultrastructure of mitochondria have been reported in several unrelated pathologies …

Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is
abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify …

Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen
species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide …

Abstract Background Glutathione S‐transferases (GSTs) polymorphisms may impact on
chronic myeloid leukemia (CML) risk or heterogeneous responses to Imatinib mesylate (IM) …

Toxicity refers to the potential of a substance such as a pesticide to cause damage to the
structure or functions of an exposed organism. Pesticides can lead to harmful biological …

Background Chronic myeloid leukemia (CML) is associated to the BCR-ABL1 oncogene and
can successfully be treated with tyrosine kinase inhibitors (TKIs). However, it remains still …