To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

The molecular background of the Ca2+-sensitizing effect of levosimendan relates to its
specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments …

Background—Takotsubo cardiomyopathy is an acute heart failure syndrome characterized
by myocardial hypocontractility from the mid left ventricle to the apex. It is precipitated by …

Background—We determined the short-term hemodynamic and clinical effects of
levosimendan, a novel calcium-sensitizing agent, in patients with decompensated heart …

Current pharmacological therapies for heart failure with reduced ejection fraction are largely
either repurposed anti‐hypertensives that blunt overactivation of the neurohormonal system …

The electrophysiological effect of levosimendan, a novel Ca2+-sensitizing positive inotropic
agent and vasodilator, was examined on rat mesenteric arterial myocytes using the patch …

Background—Levosimendan was shown to increase calcium sensitivity by a novel
mechanism and to inhibit phosphodiesterase III activity in animal myocardium. Methods and …

Aims The aim of the study was to evaluate the effects on systemic and coronary
haemodynamics and myocar-dial substrate utilization of a new calcium sensitizer …

We tested the hypothesis that levosimendan, a new positive inotropic drug that activates
adenosine triphosphate-regulated potassium (K ATP) channels in vitro, decreases …

What is known and objective Positive inotropic agents are frequently used in acute
decompensated heart failure (ADHF) due to left ventricular systolic dysfunction. These …