Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Asciminib is a potent, orally bioavailable, investigational drug that specifically and potently
inhibits the tyrosine kinase activity of native ABL1, together with that of the chimeric BCR …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor
kinase class that controls multiple signaling pathways in animal cells. SFKs activation is …

Protein post-translational modifications play key roles in multiple cellular processes by
allowing rapid reprogramming of individual protein functions. Acylation, one of the most …

Fatty acid metabolism is essential for the biogenesis of cellular components and ATP
production to sustain proliferation of cancer cells. Long-chain fatty acyl-CoA synthetases …