Bacteria have to cope with oxidative stress caused by distinct Reactive Oxygen Species
(ROS), derived not only from normal aerobic metabolism but also from oxidants present in …

Ever since the “great oxidation event,” Earth's cellular life forms had to cope with the danger
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …

Ribosome stalling during translation has recently been shown to cause neurodegeneration,
yet the signaling pathways triggered by stalled elongation complexes are unknown. To …

In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as
translation. The amplitude of translational regulation exceeds the sum of transcription …

The major human pathogen Mycobacterium tuberculosis can survive in the host organism
for decades without causing symptoms. A large cohort of Toxin–Antitoxin (TA) modules …

Besides translation, transfer RNAs (tRNAs) play many non-canonical roles in various
biological pathways and exhibit highly variable expression profiles. To unravel the emerging …

Ribosome and protein synthesis lie at the core of cell growth and are major consumers of
the cellular budget. Here we review recent progress in the coupling of ribosome synthesis …

Viruses are traditionally thought to be under selective pressure to maintain compact
genomes and thus depend on host cell translational machinery for reproduction. However …

The factors and mechanisms that govern tRNA stability in bacteria are not well understood.
Here, we investigated the influence of posttranscriptional modification of bacterial tRNAs …

Diet and bile play critical roles in shaping gut microbiota, but the molecular mechanism
underlying interplay with intestinal microbiota is unclear. Here, we showed that lemon …