Hibernators are unique among mammals in their ability to attain, withstand, and reverse low
body temperatures. Hibernators repeatedly cycle between body temperatures near zero …

Cellular and organismal homeostasis must be maintained across a body temperature (Tb)
range of 0 to 37° C during mammalian hibernation. Hibernators depress biosynthetic …

Mammals that enter deep hibernation experience extreme reductions in body temperature
and in metabolic, respiratory, and heart rates for several weeks at a time. Survival of these …

We describe two models explaining the increase in tissue nitrogen isotope ratios (δ15N) that
occurs during fasting in animals. The catabolic model posits that protein breakdown …

Mammalian hibernation involves cessation of energetically costly processes typical of
homeostatic regulation including protein synthesis. To further elucidate the mechanisms …

Differential gene expression is likely to play a significant role in determining the phenotype
of hibernation. Crucial gene products may facilitate entrance, maintenance and survival of …

Hibernation is a phenomenon characterized by annual periods of lethargy which correlate
with alterations in the thermal environment and nutritional availability. Bouts of hibernation …

The roles for both passive depression and active suppression of energy-consuming
processes in effecting the metabolic depression of a hibernator are poorly understood. The …

Mammalian hibernation in the golden-mantled ground squirrel (Spermophilus lateralis) is
characterized by dynamic changes in body temperature for the seven months of winter. Most …

The Arctic is home to animals that have taken adaptations to overwintering to extremes. In
this dissertation, I have investigated one of these adaptations, hibernation, in two species …