Preeclampsia: from cellular wellness to inappropriate cell death, and the roles of nutrition

AW Lokeswara, R Hiksas, R Irwinda… - Frontiers in Cell and …, 2021 - frontiersin.org
Preeclampsia is one of the most common obstetrical complications worldwide. The
pathomechanism of this disease begins with abnormal placentation in early pregnancy …

Choline and DHA in maternal and infant nutrition: synergistic implications in brain and eye health

JG Mun, LCL Legette, CJ Ikonte, SH Mitmesser - Nutrients, 2019 - mdpi.com
The aim of this review is to highlight current insights into the roles of choline and
docosahexaenoic acid (DHA) in maternal and infant nutrition, with special emphasis on …

Choline: exploring the growing science on its benefits for moms and babies

HW Korsmo, X Jiang, MA Caudill - Nutrients, 2019 - mdpi.com
The importance of ensuring adequate choline intakes during pregnancy is increasingly
recognized. Choline is critical for a number of physiological processes during the prenatal …

Placental metabolomics for assessment of sex-specific differences in fetal development during normal gestation

M Saoi, KM Kennedy, W Gohir, DM Sloboda… - Scientific Reports, 2020 - nature.com
The placenta is a metabolically active interfacial organ that plays crucial roles in fetal
nutrient delivery, gas exchange and waste removal reflecting dynamic maternal and fetal …

Choline

SH Zeisel, KC Klatt, MA Caudill - Advances in nutrition, 2018 - advances.nutrition.org
Choline has several important functions. These are as follows: 1) it is a source of the methyl
groups needed to make the primary methyl donor S-adenosylmethionine, 2) it is a part of the …

Prenatal interventions for fetal growth restriction in animal models: A systematic review

I Valenzuela, M Kinoshita, J van der Merwe, K Maršál… - Placenta, 2022 - Elsevier
Fetal growth restriction (FGR) in human pregnancy is associated with perinatal mortality,
short-and long-term morbidities. No prenatal therapy is currently established despite …

Placental adaptations to micronutrient dysregulation in the programming of chronic disease

P Hofstee, DR McKeating, AV Perkins… - Clinical and …, 2018 - Wiley Online Library
Poor nutrition during pregnancy is known to impair foetal development and increase the risk
of chronic disease in offspring. Both macronutrients and micronutrients are required for a …

Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation

MW Socha, W Flis, M Wartęga - Nutrients, 2024 - mdpi.com
Pregnancy is an extremely stressful period in a pregnant woman's life. Currently, women's
awareness of the proper course of pregnancy and its possible complications is constantly …

Exploring the Role of Mediterranean and Westernized Diets and Their Main Nutrients in the Modulation of Oxidative Stress in the Placenta: A Narrative Review

C García-Montero, O Fraile-Martinez, D De Leon-Oliva… - Antioxidants, 2023 - mdpi.com
Oxidative stress is a major cellular event that occurs in the placenta, fulfilling critical
physiological roles in non-pathological pregnancies. However, exacerbated oxidative stress …

Prenatal choline supplementation during mouse pregnancy has differential effects in alcohol‐exposed fetal organs

ST Kwan, DK Ricketts, BH Presswood… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Background Fetal alcohol spectrum disorders (FASD) are preventable adverse outcomes
consequent to prenatal alcohol exposure. Supplemental choline confers neuroprotection to …