Drug addiction represents a dramatic dysregulation of motivational circuits that is caused by
a combination of exaggerated incentive salience and habit formation, reward deficits and …

Background Polysubstance use (PSU) is prevalent among individuals with substance use
disorders, but the vast majority of preclinical substance use research has focused on …

The faster a drug enters the brain, the greater its addictive potential, yet the brain circuits
underlying the rate dependency to drug reward remain unresolved. With simultaneous PET …

Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …

Drug addiction or substance-use disorder is a chronically relapsing disorder that progresses
through binge/intoxication, withdrawal/negative affect and preoccupation/anticipation …

Drugs that act on the brain oxytocin (OXT) system may provide a much-needed treatment
breakthrough for substance-use disorders. Targeting the brain OXT system has the potential …

Since the introduction of intravenous drug self-administration methodology over 50 years
ago, experimental investigation of addictive behaviour has delivered an enormous body of …

Cocaine addiction is a chronic brain disease in which the drug seeking habits and profound
cognitive, emotional and motivational alterations emerge from drug-induced …

Abstract Opioid Use Disorder (OUD) is a chronic relapsing clinical condition with
tremendous morbidity and mortality that frequently persists, despite treatment, due to an …

Drug addiction is a chronic and relapsing disorder in which repeated drug exposure
compromises brain neuroplasticity. Brain areas normally involved in learning and goal …