In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

Executive summary Women's reproductive, maternal, newborn, child, and adolescent health
(RMNCAH) is a cornerstone for the healthy development of the next generation and a …

Molecular mechanisms of ovarian aging and female age-related fertility decline remain
unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and …

BACKGROUND The early onset of menopause is associated with increased risks of
cardiovascular disease and osteoporosis. As a woman's circulating anti-Müllerian hormone …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Ovarian fibrosis is a pathological condition associated with aging and is responsible for a
variety of ovarian dysfunctions. Given the known contributions of tissue fibrosis to …

Reproductive ageing in females is defined by a progressive decline in follicle number and
oocyte quality. This is a natural process that leads to the loss of fertility and ovarian function …

During ageing, the secretory patterns of the hormones produced by the hypothalamic–
pituitary axis change, as does the sensitivity of the axis to negative feedback by end …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Summary The 2016 US Selected Practice Recommendations for Contraceptive Use (US
SPR) addresses a select group of common, yet sometimes controversial or complex, issues …