Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …

Idiosyncratic drug-induced liver injury (DILI) is a major clinical problem and poses a
considerable challenge for drug development as an increasing number of successfully …

To the Editor: Linezolid belongs to a family of antimicrobial agents (oxazolidinones) that
inhibit bacterial protein synthesis by preventing the fusion of 30S and 50S ribosomal …

The objective of the present study was to determine the mitochondrial toxicity mechanisms of
linezolid-related hyperlactatemia. Five patients on a long-term schedule of linezolid …

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and an active
constituent of the highly active antiretroviral therapy regime. It has significantly contributed in …

Abstract Changes in mitochondrial DNA copy number and increases in mitochondrial DNA
mutations, especially deletions, have been associated with exposure to mutagens and with …

Several drugs are currently used that can significantly prolong the course of the infection
with the human immunodeficiency virus (HIV), the cause of the acquired immunodeficiency …

A longer life expectancy and a high prevalence of tobacco smoking among HIV patients
have led to an increasing cumulative exposure to tobacco in this community. Clinical …

Kidney disease represents an important health concern among HIV-infected individuals,
with an estimated prevalence ranging between 2.4 and 17%. The widespread use of …