PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
The comings and goings of PARP-1 in response to DNA damage
JM Pascal - DNA repair, 2018 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease
B Lüscher, M Bütepage, L Eckei, S Krieg… - Chemical …, 2018 - ACS Publications
Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …
PARP-1 activation requires local unfolding of an autoinhibitory domain
JM Dawicki-McKenna, MF Langelier, JE DeNizio… - Molecular cell, 2015 - cell.com
Summary Poly (ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational
modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks …
modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks …
Serine is the major residue for ADP-ribosylation upon DNA damage
Poly (ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-
ribosylation (ADPr), a reversible modification of proteins that regulates many different …
ribosylation (ADPr), a reversible modification of proteins that regulates many different …
Serine ADP-ribosylation reversal by the hydrolase ARH3
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls
many cellular processes, including DNA repair, transcription, chromatin regulation and …
many cellular processes, including DNA repair, transcription, chromatin regulation and …
Poly (ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon
activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose …
activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose …
Readers of poly (ADP-ribose): designed to be fit for purpose
F Teloni, M Altmeyer - Nucleic acids research, 2015 - academic.oup.com
Post-translational modifications (PTMs) regulate many aspects of protein function and are
indispensable for the spatio-temporal regulation of cellular processes. The proteome-wide …
indispensable for the spatio-temporal regulation of cellular processes. The proteome-wide …
Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …