Modulation of neurotrophic signaling pathways by polyphenols

F Moosavi, R Hosseini, L Saso… - Drug design, development …, 2015 - Taylor & Francis
Polyphenols are an important class of phytochemicals, and several lines of evidence have
demonstrated their beneficial effects in the context of a number of pathologies including …

[HTML][HTML] The cellular model for Alzheimer's disease research: PC12 cells

D Xie, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …

[HTML][HTML] Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models

N Cardenas-Rodriguez, B Huerta-Gertrudis… - International journal of …, 2013 - mdpi.com
Oxidative stress, a state of imbalance in the production of reactive oxygen species and
nitrogen, is induced by a wide variety of factors. This biochemical state is associated with …

Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth

YY Hsu, YT Tseng, YC Lo - Toxicology and applied pharmacology, 2013 - Elsevier
Reactive oxygen intermediates production and apoptotic damage induced by high glucose
are major causes of neuronal damage in diabetic neuropathy. Berberine (BBR), a natural …

Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells …

CW Phan, GS Lee, SL Hong, YT Wong, R Brkljača… - Food & Function, 2014 - pubs.rsc.org
Hericium erinaceus (Bull.: Fr.) Pers. is an edible and medicinal mushroom used traditionally
to improve memory. In this study, we investigated the neuritogenic effects of hericenones …

Target-based selection of flavonoids for neurodegenerative disorders

QRD Jones, J Warford, HPV Rupasinghe… - Trends in …, 2012 - cell.com
Habitual consumption of dietary flavonoids known to improve mitochondrial bioenergetics
and inhibit various secondary sources of reactive oxygen species (ROS) reduces the risk for …

[HTML][HTML] Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats

S Lai, Z Gu, M Zhao, X Li, Y Ma, L Luo… - Neural regeneration …, 2017 - journals.lww.com
Although numerous studies have examined the neurotoxicity of acrylamide in adult animals,
the effects on neuronal development in the embryonic and lactational periods are largely …

Disease chemopreventive effects and molecular mechanisms of hydroxylated polymethoxyflavones

CS Lai, JC Wu, CT Ho, MH Pan - BioFactors, 2015 - Wiley Online Library
Recent increasing attention in research of polymethoxyflavones (PMFs) from Citrus genus
because of their wide range of biological properties has been reported in various studies …

[HTML][HTML] Beneficial effects of citrus-derived polymethoxylated flavones for central nervous system disorders

K Matsuzaki, Y Ohizumi - Nutrients, 2021 - mdpi.com
The number of patients with central nervous system disorders is increasing. Despite diligent
laboratory and clinical research over the past 30 years, most pharmacologic options for the …

[HTML][HTML] Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 cells

LF Lin, SP Chiu, MJ Wu, PY Chen, JH Yen - 2012 - journals.plos.org
Luteolin (3′, 4′, 5, 7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to
exert neurotrophic properties that are associated with its capacity to promote neuronal …