The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in
regulating inflammation. Inflammation is associated with accumulation and turnover of HA …

Wound healing involves a series of carefully modulated steps, from initial injury and blood
clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between …

Hyaluronan is a straight chain, glycosaminoglycan polymer of the extracellular matrix
composed of repeating units of the disaccharide [-d-glucuronic acid-β1, 3-N-acetyl-d …

Metastatic complications are responsible for more than 90% of cancer-related deaths. The
progression from an isolated tumor to disseminated metastatic disease is a multistep …

The hyaluronidases (Hyals) are classes of enzymes that degrade, predominantly,
hyaluronan (HA). The term “hyaluronidase” is somewhat of a misnomer since they have the …

Publisher Summary CD44 is a ubiquitous multistructural and multifunctional cell surface
adhesion molecule involved in cell–cell and cell–matrix interactions. CD44s is a single …

Over the past 60 years, hyaluronidase has been successfully utilized in ophthalmic surgery
and is now being implemented in dermatosurgery as well as in other surgical disciplines …

A new pathway of intermediary metabolism is described involving the catabolism of
hyaluronan. The cell surface hyaluronan receptor, CD44, two hyaluronidases, Hyal-1 and …

Myofascial pain syndrome (MPS) is described as the muscle, sensory, motor, and autonomic
nervous system symptoms caused by stimulation of myofascial trigger points (MTP). The …