The separation and detection of isomers remains a challenge for many areas of mass
spectrometry. This article highlights laser photodissociation and ion mobility strategies that …

The catalytic strategies of small self-cleaving ribozymes often involve interactions between
nucleobases and the ribonucleic acid (RNA) backbone. Here we show that multiply …

2′-Deoxyguanosine (dGuo) and guanosine (Guo) are fundamental building blocks of DNA
and RNA nucleic acids. In order to understand the effects of sodium cationization on the gas …

The molecular family of nucleotide triphosphates (NTPs), with adenosine 5′-triphosphate
(ATP) as its best-known member, is of high biochemical importance as their phosphodiester …

Thymidine (dThd) is a fundamental building block of DNA nucleic acids, whereas 5-
methyluridine (Thd) is a common modified nucleoside found in tRNA. In order to determine …

The chemical difference between DNA and RNA nucleosides is their 2′-hydrogen versus
2′-hydroxyl substituents. Modification of the ribosyl moiety at the 2′-position and 2′-O …

The gas-phase conformations of the protonated forms of thymidine-5′-monophosphate and
uridine-5′-monophosphate,[pdThd+ H]+ and [pUrd+ H]+, are investigated by infrared …

Fluorinated nucleosides are well-established as anticancer and antiviral medications. As
with many pharmaceuticals, the effects of fluorine modifications are often only partially …

OH⋅‐induced oxidation products of DNA nucleosides and nucleotides have been
structurally characterized by collision‐induced dissociation tandem mass spectrometry (CID …

Synergistic infrared multiple photon dissociation (IRMPD) action spectroscopy experiments
and electronic structure calculations revealed that both 2, 4-dihydroxy tautomers and O2 …