Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics

Y Gupta, OV Savytskyi, M Coban, A Venugopal… - Molecular Aspects of …, 2023 - Elsevier
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …

Long COVID, the brain, nerves, and cognitive function

AB Reiss, C Greene, C Dayaramani… - Neurology …, 2023 - mdpi.com
SARS-CoV-2, a single-stranded RNA coronavirus, causes an illness known as coronavirus
disease 2019 (COVID-19). Long-term complications are an increasing issue in patients who …

SARS-CoV-2 and the nervous system: current perspectives

A Pattanaik, S Bhandarkar B, L Lodha, S Marate - Archives of Virology, 2023 - Springer
SARS-CoV-2 infection frequently causes neurological impairment in both adults and
children. Recent publications have described significant aspects of the viral pathophysiology …

Intrinsic factors behind long‐COVID: II. SARS‐CoV‐2, extracellular vesicles, and neurological disorders

YA El‐Maradny, A Rubio‐Casillas… - Journal of Cellular …, 2023 - Wiley Online Library
With the decline in the number of new Severe Acute Respiratory Syndrome Coronavirus 2
(SARS‐CoV‐2) infections, the World Health Organization announced the end of the SARS …

Long-term effects of SARS-CoV-2 in the brain: clinical consequences and molecular mechanisms

AC Granholm - Journal of Clinical Medicine, 2023 - mdpi.com
Numerous investigations have demonstrated significant and long-lasting neurological
manifestations of COVID-19. It has been suggested that as many as four out of five patients …

[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …

AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …

Infectious diseases

H Li, N Terrando, HA Gelbard - Microglia: Physiology, Pathophysiology …, 2024 - Springer
Microglia, brain-resident innate immune cells, have been extensively studied in
neurodegenerative contexts like Alzheimer's disease. The Coronavirus disease 2019 …

The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D …

Y Kase, I Sonn, M Goto, R Murakami, T Sato… - Experimental …, 2023 - Elsevier
COVID-19 causes neurological damage, systemic inflammation, and immune cell
abnormalities. COVID-19-induced neurological impairment may be caused by severe acute …

Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of …

MA Erickson, AF Logsdon, EM Rhea… - Brain, behavior, and …, 2023 - Elsevier
COVID-19 and especially Long COVID are associated with severe CNS symptoms and may
place persons at risk to develop long-term cognitive impairments. Here, we show that two …