The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

R Wang, B Li, SM Lam, G Shui - Journal of genetics and genomics, 2020 - Elsevier
Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …

The sponge microbiome project

L Moitinho-Silva, S Nielsen, A Amir, A Gonzalez… - …, 2017 - academic.oup.com
Rhododendron delavayi Franch. is globally famous as an ornamental plant. Its distribution in
southwest China covers several different habitats and environments. However, not much …

[PDF][PDF] Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis

C Zeng, B Wen, G Hou, L Lei, Z Mei, X Jia, X Chen… - …, 2017 - academic.oup.com
Psoriasis is a common and chronic inflammatory skin disease that is complicated by gene–
environment interactions. Although genomic, transcriptomic, and proteomic analyses have …

Lipidomics of bioactive lipids in Alzheimer's and Parkinson's diseases: Where are we?

V Chiurchiù, M Tiberi, A Matteocci, F Fazio… - International Journal of …, 2022 - mdpi.com
Lipids are not only constituents of cellular membranes, but they are also key signaling
mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive …

Untargeted lipidomics reveals progression of early Alzheimer's disease in APP/PS1 transgenic mice

X Zhang, W Liu, J Zan, C Wu, W Tan - Scientific reports, 2020 - nature.com
Alzheimer's Disease (AD) is closely connected to aberrant lipid metabolism. However, how
early AD-like pathology synchronously influences brain and plasma lipidome in AD mice …

The Role of Oxidative Stress‐Induced Epigenetic Alterations in Amyloid‐β Production in Alzheimer's Disease

L Zuo, BT Hemmelgarn, CC Chuang… - Oxidative medicine and …, 2015 - Wiley Online Library
An increasing number of studies have proposed a strong correlation between reactive
oxygen species (ROS)‐induced oxidative stress (OS) and the pathogenesis of Alzheimer's …

Revealing the role of glycerophospholipid metabolism in asthma through plasma lipidomics

S Wang, K Tang, Y Lu, Z Tian, Z Huang, M Wang… - Clinica chimica acta, 2021 - Elsevier
Lipid mediators play an essential role in the pathogenesis of asthma. Many studies on the
differential expression of sphingolipids and fatty acid exist, but relatively few concerned …

Multi-omics analysis reveals the toxic mechanism of ammonia-enhanced Microcystis aeruginosa exposure causing liver fat deposition and muscle nutrient loss in …

K Ou-Yang, Y Kuang, H Yang, Y He, L Wang… - Journal of Hazardous …, 2024 - Elsevier
Microcystis aeruginosa and ammonia pollution are two important environmental stress
factors in water eutrophication. Herein, we simulated environmental conditions to investigate …

Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis–mass spectrometry

R González‐Domínguez, A García… - …, 2014 - Wiley Online Library
There is high interest in the discovery of early diagnostic biomarkers of Alzheimer's disease,
for which metabolomics exhibits a great potential. In this work, a metabolomic approach …