Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …

Cancer remains a major cause of morbidity and mortality irrespective of the type of
conventional chemotherapy. Therefore, there is an urgent need for new and effective …

The analysis of omic data depends on machine‐readable information about protein
interactions, modifications, and activities as found in protein interaction networks, databases …

Abstract p28 is an anionic cell-penetrating peptide of 28 amino acids that activates wild-type
and mutated p53, leading subsequently to selective inhibition of CDK2 and cyclin A …

Proteins are major drug targets, and drug–target interaction identification and analysis are
important factors for drug discovery. Atomic force microscopy (AFM) is a powerful tool …

Azurin secreted by Pseudomonas aeruginosa is an anticancer bacteriocin, which
preferentially enters human cancer cells and induces apoptosis or growth inhibition. It turns …

Despite an enhanced permeability and retention effect typical of many solid tumors, drug
penetration is not always sufficient. Possible strategies for the drug delivery improvement …

Protein–protein interactions (PPIs) between the B-cell lymphoma 2 (Bcl-2) family are
considered a major driving force in cell cycle regulation and signaling. However, how this …

Understanding the mechanisms that regulate cancer progression is pivotal for the
development of new therapies. Although p53 is mutated in half of human cancers, its family …

Surface Plasmon Resonance (SPR) is a powerful technique to study the kinetics of
biomolecules undergoing biorecognition processes, particularly suited for protein-protein …