Profiling prostate cancer therapeutic resistance
CA Wade, N Kyprianou - International journal of molecular sciences, 2018 - mdpi.com
The major challenge in the treatment of patients with advanced lethal prostate cancer is
therapeutic resistance to androgen-deprivation therapy (ADT) and chemotherapy …
therapeutic resistance to androgen-deprivation therapy (ADT) and chemotherapy …
Therapeutic strategies to target the androgen receptor
The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and
the support of male sexual-related functions, as well as in the progression of prostate …
the support of male sexual-related functions, as well as in the progression of prostate …
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
2, 4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of
AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) …
AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) …
Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment
Androgen receptor (AR) antagonists, such as enzalutamide, have had a major impact on the
treatment of metastatic castration-resistant prostate cancer (CRPC). However, even with the …
treatment of metastatic castration-resistant prostate cancer (CRPC). However, even with the …
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
F Li, M Han, P Dai, W Xu, J He, X Tao, Y Wu… - Nature …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global public …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global public …
SOX2 mediates metabolic reprogramming of prostate cancer cells
New strategies are needed to predict and overcome metastatic progression and therapy
resistance in prostate cancer. One potential clinical target is the stem cell transcription factor …
resistance in prostate cancer. One potential clinical target is the stem cell transcription factor …
A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer
Increased expression of the full-length androgen receptor (AR-FL) and AR splice variants
(AR-Vs) drives the progression of castration-resistant prostate cancer (CRPC). The levels of …
(AR-Vs) drives the progression of castration-resistant prostate cancer (CRPC). The levels of …
Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
Background Metabolic reprograming, non-mutational epigenetic changes, increased cell
plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this …
plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this …
Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol‐dependent manner
SE Henrich, KM McMahon… - Journal of …, 2020 - Wiley Online Library
Primary tumours can establish long‐range communication with distant organs to transform
them into fertile soil for circulating tumour cells to implant and proliferate, a process called …
them into fertile soil for circulating tumour cells to implant and proliferate, a process called …