The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Cancer accounts for 13% of the yearly total mortality worldwide. Most cancer deaths are the
sequel of metastatic diseases rather than of primary tumor growth. Thus, the major challenge …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is characterized by high levels of
fibrosis, termed desmoplasia, which is thought to hamper the efficacy of therapeutics treating …

Pancreatic stellate cells (PSCs) produce the stromal reaction in pancreatic cancer (PC), and
their interaction with cancer cells facilitates cancer progression. This study investigated the …

Background Alterations towards a permissive stromal microenvironment provide important
cues for tumor growth, invasion, and metastasis. In this study, Fibroblast activation protein …

Background Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and
is characterized by an abundant tumor stroma known to interact with the cancer cells, and to …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has
received little attention until recent times. Given that treatments focusing on pancreatic …

Background & Aims Pancreatic tumors undergo rapid growth and progression, become
resistant to chemotherapy, and recur after surgery. We studied the functions of the solute …

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma
(PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance …

Although results of cancer treatment have improved steadily, metastatic solid tumors can be
cured only rarely and therefore new modalities are needed. Tumors often become apoptosis …