[HTML][HTML] Synthetic and natural guanidine derivatives as antitumor and antimicrobial agents: A review
AR Gomes, CL Varela, AS Pires… - Bioorganic …, 2023 - Elsevier
Guanidines are fascinating small nitrogen-rich organic compounds, which have been
frequently associated with a wide range of biological activities. This is mainly due to their …
frequently associated with a wide range of biological activities. This is mainly due to their …
[HTML][HTML] Drug discovery for cutaneous leishmaniasis: a review of developments in the past 15 years
HN Corman, CW McNamara, MA Bakowski - Microorganisms, 2023 - mdpi.com
Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …
Facile synthesis, characterization, antioxidant activity, and antibacterial activity of carboxymethyl inulin salt derivatives
J Zhang, W Tan, P Zhao, Y Mi, Z Guo - International Journal of Biological …, 2022 - Elsevier
A series of novel carboxymethyl inulin derivatives bearing thiosemicarbazide salts,
aminoguanidine salts, and aniline salts were prepared via a facile method and employed to …
aminoguanidine salts, and aniline salts were prepared via a facile method and employed to …
[HTML][HTML] Leishmanicidal Activity of Guanidine Derivatives against Leishmania infantum
FS Almeida, VP Moreira, ES Silva, LL Cardoso… - Tropical Medicine and …, 2023 - mdpi.com
Leishmaniasis is a neglected tropical infectious disease with thousands of cases annually; it
is of great concern to global health, particularly the most severe form, visceral leishmaniasis …
is of great concern to global health, particularly the most severe form, visceral leishmaniasis …
Development of New Leishmanicidal Compounds via Bioconjugation of Antimicrobial Peptides and Antileishmanial Guanidines
NCS Costa, LR Dos Anjos, JVM de Souza… - ACS …, 2023 - ACS Publications
Leishmaniasis refers to a collection of diseases caused by protozoa from the Leishmania
genus. These diseases, along with other parasitic afflictions, pose a significant public health …
genus. These diseases, along with other parasitic afflictions, pose a significant public health …
[HTML][HTML] Novel Selective and Low-Toxic Inhibitor of LmCPB2.8ΔCTE (CPB) One Important Cysteine Protease for Leishmania Virulence
Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of
the genus Leishmania. In the search for newer, safer, and more effective antileishmanial …
the genus Leishmania. In the search for newer, safer, and more effective antileishmanial …
[HTML][HTML] Evidence of Guanidines Potential against Leishmania (Viannia) braziliensis: Exploring In Vitro Effectiveness, Toxicities and of Innate Immunity Response …
LR Dos Anjos, VMR de Souza, YAA Machado… - Biomolecules, 2023 - mdpi.com
Leishmaniasis is a complex group of infectious and parasitic diseases that afflict many
thousands of individuals across five continents. Leishmaniasis treatment remains a …
thousands of individuals across five continents. Leishmaniasis treatment remains a …
[HTML][HTML] New ferrocene integrated amphiphilic guanidines: Synthesis, spectroscopic elucidation, DFT calculation and in vitro α-amylase and α-glucosidase inhibition …
S Zubair, A Badshah, J Patujo, M Khan, A Raheel… - Heliyon, 2023 - cell.com
Abstract Three N, N', N ″-trisubstituted ferrocenyl guanidines (MG-10, MG-12 and MG-14)
were synthesized, characterized by several analytical methods such as FT-IR, 1 H and 13 C …
were synthesized, characterized by several analytical methods such as FT-IR, 1 H and 13 C …
Exploring the antileishmanial activity of N1,N2-disubstituted-benzoylguanidines: synthesis and molecular modeling studies
KM Santiago-Silva, BTS Bortoleti, TO Brito… - Journal of …, 2022 - Taylor & Francis
In this report, we describe the synthesis and evaluation of nine N 1, N 2-disubstituted-
benzoylguanidines against promastigotes and amastigotes forms of Leishmania …
benzoylguanidines against promastigotes and amastigotes forms of Leishmania …
Improved Synthetic Methodology, Substrate Scope and X‐ray Crystal Structure for N, N'‐disubstituted Guanidines
Guanidine is a privileged scaffold in drug discovery. Herein we report our investigations into
the acid promoted amination of pyrimidine‐bearing cyanamide to produce N, N' …
the acid promoted amination of pyrimidine‐bearing cyanamide to produce N, N' …