Therapy resistance or tumor relapse in cancer is common. Tumors develop resistance to
chemotherapeutic through a variety of mechanisms, with tumor microenvironment (TM) …

One of the undeniable issues with cancer eradication is the evolution of chemoresistance in
due course of treatment, and the mechanisms of chemoresistance have been the subject of …

Background The posttranscriptional modifications of transfer RNA (tRNA) are critical for all
aspects of the tRNA function and have been implicated in the tumourigenesis and …

Diabetic nephropathy is characterized by damage to both the glomerulus and
tubulointerstitium, but relatively little is known about accompanying cell-specific changes in …

Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether
these alterations contribute to disease pathogenesis is largely unknown. To study the role of …

Background Germ cell tumors (GCT) might undergo transformation into a somatic-type
malignancy (STM), resulting in a cell fate switch to tumors usually found in somatic tissues …

Background Pleural malignant mesothelioma (MM) is a deadly tumour predominantly
associated with asbestos exposure. A reliable diagnostic and prognostic marker for MM will …

Aims Chronic kidney disease (CKD) is widely prevalent and independently increases
cardiovascular risk. Cardiovascular risk prediction tools derived in the general population …

Background & Aims Biliary atresia (BA) is poorly understood and leads to liver
transplantation (LT), with the requirement for and associated risks of lifelong …

Biliary atresia (BA) is a rare pediatric cholangiopathy characterized by fibrosclerosing
obliteration of the extrahepatic bile ducts, leading to cholestasis, fibrosis, cirrhosis, and …