IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …

Abstract Interleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in
multiple cellular responses, including tumor development. However, the origin and functions …

IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the
stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte …

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as
systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease …

Apoptosis is a carefully orchestrated and tightly controlled form of cell death, conserved
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …

Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …