Growth, replication and division enable evolution of coacervate protocells
AD Slootbeek, MHI van Haren, IBA Smokers… - Chemical …, 2022 - pubs.rsc.org
Living and proliferating cells undergo repeated cycles of growth, replication and division, all
orchestrated by complex molecular networks. How a minimal cell cycle emerged and helped …
orchestrated by complex molecular networks. How a minimal cell cycle emerged and helped …
Bio‐inspired functional coacervates: Special Issue: Emerging Investigators
S Chen, Q Guo, J Yu - Aggregate, 2022 - Wiley Online Library
Many functional coacervates have been identified in biological systems, which have
attracted widespread interest. Coacervation is a liquid–liquid phase separation (LLPS) …
attracted widespread interest. Coacervation is a liquid–liquid phase separation (LLPS) …
Biomolecular condensates create phospholipid-enriched microenvironments
JG Dumelie, Q Chen, D Miller, N Attarwala… - Nature Chemical …, 2024 - nature.com
Proteins and RNA can phase separate from the aqueous cellular environment to form
subcellular compartments called condensates. This process results in a protein–RNA …
subcellular compartments called condensates. This process results in a protein–RNA …
Ribozyme activity modulates the physical properties of RNA–peptide coacervates
Condensed coacervate phases are now understood to be important features of modern cell
biology, as well as valuable protocellular models in origin-of-life studies and synthetic …
biology, as well as valuable protocellular models in origin-of-life studies and synthetic …
Complex Coacervates as a Promising Vehicle for mRNA Delivery: A Comprehensive Review of Recent Advances and Challenges
Messenger RNA (mRNA)-based therapies have gained significant attention, following the
successful deployment of mRNA-based COVID-19 vaccines. Compared with traditional …
successful deployment of mRNA-based COVID-19 vaccines. Compared with traditional …
Hybrid Protocells Based on Coacervate‐Templated Fatty Acid Vesicles Combine Improved Membrane Stability with Functional Interior Protocytoplasm
Prebiotically‐plausible compartmentalization mechanisms include membrane vesicles
formed by amphiphile self‐assembly and coacervate droplets formed by liquid–liquid phase …
formed by amphiphile self‐assembly and coacervate droplets formed by liquid–liquid phase …
RNA folding studies inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life
Compartmentalization of RNA in biopolymer-rich membraneless organelles is now
understood to be pervasive and critical for the function of extant biology and has been …
understood to be pervasive and critical for the function of extant biology and has been …
The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors
L Statello, JM Fernandez-Justel, J González… - Nature …, 2024 - nature.com
Besides the well-characterized protein network involved in the replication stress response,
several regulatory RNAs have been shown to play a role in this critical process. However, it …
several regulatory RNAs have been shown to play a role in this critical process. However, it …
Charge-Patterned Disordered Peptides Tune Intracellular Phase Separation in Bacteria
Subcellular phase-separated compartments, known as biomolecular condensates, play an
important role in the spatiotemporal organization of cells. To understand the sequence …
important role in the spatiotemporal organization of cells. To understand the sequence …
Aging RNA granule dynamics in neurodegeneration
Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic
causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and …
causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and …