Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

Contraction of striated muscles is driven by cyclic interactions of myosin head projecting
from the thick filament with actin filament and is regulated by Ca2+ released from …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Rationale: High-myofilament Ca2+ sensitivity has been proposed as a trigger of disease
pathogenesis in familial hypertrophic cardiomyopathy (HCM) on the basis of in vitro and …

Interaction of the M-protein of group A Streptococcus (GAS) with its numerous host binding
partners might assist the bacteria in evading host immune responses. Although the …

More than a century of research on the Frank–Starling Law has significantly advanced our
knowledge about the working heart. The Frank–Starling Law mandates that the heart is able …

Sixteen years ago, mutations in cardiac troponin (Tn) T and α-tropomyosin were linked to
familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β …

The molecular mechanism by which Ca 2+ binding and phosphorylation regulate muscle
contraction through Troponin is not yet fully understood. Revealing the differences between …

Cardiac contraction depends on molecular interactions among sarcomeric proteins
coordinated by the rising and falling intracellular Ca2+ levels. Cardiac thin filament (cTF) …