[HTML][HTML] Epsilon-poly-L-lysine: recent advances in biomanufacturing and applications

L Wang, C Zhang, J Zhang, Z Rao, X Xu… - … in Bioengineering and …, 2021 - frontiersin.org
ε-poly-L-lysine (ε-PL) is a naturally occurring poly (amino acid) of varying polymerization
degree, which possesses excellent antimicrobial activity and has been widely used in food …

Biosynthetic pathways to nonproteinogenic α-amino acids

JB Hedges, KS Ryan - Chemical reviews, 2019 - ACS Publications
Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

Modified nanoporous titanium dioxide as a novel carrier for enzyme immobilization

L Wu, S Wu, Z Xu, Y Qiu, S Li, H Xu - Biosensors and Bioelectronics, 2016 - Elsevier
Abstract ε-Poly-l-lysine (EPL)-modified mesoporous titanium dioxide (M-TiO 2) was
assembled through the electrostatic attraction between EPL and M-TiO 2. Through …

[HTML][HTML] First direct evidence for direct cell-membrane penetrations of polycationic homopoly (amino acid) s produced by bacteria

Y Takeuchi, K Ushimaru, K Kaneda… - Communications …, 2022 - nature.com
Bacteria produce polycationic homopoly (amino acid) s, which are characterized by
isopeptide backbones. Although the biological significance of polycationic homopoly (amino …

Recent advances in the biotechnological production of microbial poly(ɛ-l-lysine) and understanding of its biosynthetic mechanism

Z Xu, Z Xu, X Feng, D Xu, J Liang, H Xu - Applied microbiology and …, 2016 - Springer
Abstract Poly (ɛ-l-lysine)(ɛ-PL) is an unusual biopolymer composed of l-lysine connected
between α-carboxyl and ɛ-amino groups. It has been used as a preservative in food and …

Engineering functional homopolymeric amino acids: from biosynthesis to design

Y Qiu, D Xu, P Lei, S Li, H Xu - Trends in Biotechnology, 2023 - cell.com
Homopolymeric amino acids (HPAs) are a class of microbial polymers that can be classified
into two categories: anionic and cationic HPAs. Notable examples include γ-poly-glutamic …

Discovery of a Short-Chain ε-Poly-l-lysine and Its Highly Efficient Production via Synthetase Swap Strategy

D Xu, R Wang, Z Xu, Z Xu, S Li, M Wang… - Journal of agricultural …, 2019 - ACS Publications
ε-Poly-l-lysine (ε-PL) is a natural antimicrobial cationic peptide, which is generally
recognized as safe for use as a food preservative. To date, the production capacity of strains …

Enhancement of metabolic flux toward ε-poly-l-lysine biosynthesis by targeted inactivation of concomitant polyene macrolide biosynthesis in Streptomyces albulus

K Yamanaka, Y Hamano, T Oikawa - Journal of bioscience and …, 2020 - Elsevier
ε-Poly-l-lysine (ε-PL) produced as a secondary metabolite of Streptomyces albulus has long
been used as a natural food preservative in a number of countries, including Japan, the …

An innovative method for immobilizing sucrose isomerase on ε-poly-l-lysine modified mesoporous TiO2

L Wu, Y Liu, B Chi, Z Xu, X Feng, S Li, H Xu - Food chemistry, 2015 - Elsevier
Sucrose isomerase (SIase) is the key enzyme in the enzymatic synthesis of isomaltulose.
Mesoporous titanium dioxide (M-TiO 2) and ε-poly-l-lysine-functionalized M-TiO 2 (EPL-M …

Efficiently activated ε‐poly‐L‐lysine production by multiple antibiotic‐resistance mutations and acidic pH shock optimization in Streptomyces albulus

L Wang, S Li, J Zhao, Y Liu, X Chen, L Tang… - …, 2019 - Wiley Online Library
Abstract ε‐Poly‐L‐lysine (ε‐PL) is a food additive produced by Streptomyces and is widely
used in many countries. Working with Streptomyces albulus FEEL‐1, we established a …