Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …
health. Their disruption is associated with detrimental physiological consequences …
The neurobiological basis of narcolepsy
CE Mahoney, A Cogswell, IJ Koralnik… - Nature Reviews …, 2019 - nature.com
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
T cells in patients with narcolepsy target self-antigens of hypocretin neurons
Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce
hypocretin. The close association with HLA-DQB1* 06: 02, evidence for immune …
hypocretin. The close association with HLA-DQB1* 06: 02, evidence for immune …
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
We explored the role of hypocretins in human narcolepsy through histopathology of six
narcolepsy brains and mutation screening of Hcrt, Hcrtr1 and Hcrtr2 in 74 patients of various …
narcolepsy brains and mutation screening of Hcrt, Hcrtr1 and Hcrtr2 in 74 patients of various …
AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland
Background Narcolepsy is a chronic sleep disorder with strong genetic predisposition
causing excessive daytime sleepiness and cataplexy. A sudden increase in childhood …
causing excessive daytime sleepiness and cataplexy. A sudden increase in childhood …
Physiology of gangliosides and the role of antiganglioside antibodies in human diseases
Gangliosides are structurally and functionally polymorphic sialic acid containing
glycosphingolipids that are widely distributed in the human body. They play important roles …
glycosphingolipids that are widely distributed in the human body. They play important roles …
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
Context Narcolepsy, a neurological disorder affecting 1 in 2000 individuals, is associated
with HLA-DQB1* 0602 and low cerebrospinal fluid (CSF) hypocretin (orexin) levels …
with HLA-DQB1* 0602 and low cerebrospinal fluid (CSF) hypocretin (orexin) levels …
Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin)
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …
Clinical considerations for the diagnosis of idiopathic hypersomnia
Y Dauvilliers, RK Bogan, I Arnulf, TE Scammell… - Sleep Medicine …, 2022 - Elsevier
Idiopathic hypersomnia is a sleep disorder of neurologic origin characterized by excessive
daytime sleepiness, with sleep inertia, long, unrefreshing naps, and prolonged nighttime …
daytime sleepiness, with sleep inertia, long, unrefreshing naps, and prolonged nighttime …
Complex HLA-DR and-DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
E Mignot, L Lin, W Rogers, Y Honda, X Qiu… - The American Journal of …, 2001 - cell.com
Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated
hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1* 0602. Few studies have …
hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1* 0602. Few studies have …