Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …

Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …

Cellular microtubules are marked by abundant and evolutionarily conserved post‐
translational modifications that have the potential to tune their functions. This review focuses …

The microtubule cytoskeleton is assembled from the α-and β-tubulin subunits of the
canonical tubulin heterodimer, which polymerizes into microtubules, and a small number of …

The fine tuning of proliferation and neurogenesis, neuronal migration and differentiation and
connectivity underlies the proper development of the cerebral cortex. Mutations in genes …

We have developed a protocol that allows rapid and efficient purification of native, active
tubulin from a variety of species and tissue sources by affinity chromatography. The affinity …

To understand the human response to DNA damage, we used microarrays to measure
transcriptional responses of 10 000 genes to ionizing radiation (IR) and ultraviolet radiation …

The cellular functions of the microtubule (MT) cytoskeleton range from relatively simple to
amazingly complex. Assembled from tubulin, a heterodimeric protein with α-and β-tubulin …

We have successfully used mutagenesis to engineer Taxol (paclitaxel) binding activity in
Saccharomyces cerevisiae tubulin. Taxol, a successful antitumor agent, acts by promoting …