Supercritical carbon dioxide as a green alternative to achieve drug complexation with cyclodextrins

M Banchero - Pharmaceuticals, 2021 - mdpi.com
Cyclodextrins are widely used in pharmaceutics to enhance the bioavailability of many
drugs. Conventional drug/cyclodextrin complexation techniques suffer from many …

[HTML][HTML] Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

DB Scariot, A Staneviciute, J Zhu, X Li… - Frontiers in Cellular …, 2022 - frontiersin.org
Nanotechnology is revolutionizing many sectors of science, from food preservation to
healthcare to energy applications. Since 1995, when the first nanomedicines started being …

Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin

J Ndayishimiye, Y Cao, T Kumeria… - Journal of Materials …, 2021 - pubs.rsc.org
Vancomycin (Van) is a key antibiotic of choice for the treatment of systemic methicillin
resistant Staphylococcus aureus (MRSA) infections. However, due to its poor membrane …

Preparation of solid dispersions of simvastatin and soluplus using a single-step organic solvent-free supercritical fluid process for the drug solubility and dissolution …

U Nandi, AL Ajiboye, P Patel, D Douroumis, V Trivedi - Pharmaceuticals, 2021 - mdpi.com
The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO2)
processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in …

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

PY Xu, RK Kankala, YW Li, SB Wang… - Regenerative …, 2022 - academic.oup.com
Despite the success, it is highly challenging to battle against pathogenic biofilms-based
chronic bacterial infections by conventional antibiotic therapy. Herein, we report a near …

Aggregation-induced emission (AIE) nanoparticles based on γ-cyclodextrin and their applications in biomedicine

L Guan, Z Zeng, W Liu, T Wang, S Tian, S Hu… - Carbohydrate …, 2022 - Elsevier
Abstract Amphiphilic AIE nanoparticles (CD-TPE) were obtained by linking γ-cyclodextrin (γ-
CD) and 1, 2-diphenyl-1, 2-(p-hydroxyphenyl)-ethylene (OH-TPE-OH) by an esterification …

Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole

J Ndayishimiye, T Kumeria, A Popat… - International Journal of …, 2022 - Elsevier
When administered orally, the bioavailability of drugs is strongly influenced by their aqueous
solubility and permeability. Although solubility-enabling excipients can improve the aqueous …

Development of highly stable ICG-polymeric nanoparticles with ultra-high entrapment efficiency using supercritical antisolvent (SAS)-combined solution casting …

PY Xu, RK Kankala, SB Wang, AZ Chen - International Journal of …, 2022 - Elsevier
Indocyanine green (ICG), a water-soluble near-infrared (NIR) photosensitizer, has been
enormously regarded in tumor diagnosis and phototherapy. Although tremendous progress …

Drug-excipient compatibility studies in formulation development: A case study with benznidazole and monoglycerides

RH Saatkamp, BM Dos Santos, MP Sanches… - … of Pharmaceutical and …, 2023 - Elsevier
Monoglycerides (MGs) such as glycerol monolaurate (GML) and glycerol monostearate
(GMS) have been used as excipients in oral formulations because of their emulsifying effect …

Effect of the carrier on the coprecipitation of curcumin through supercritical-assisted atomization

I De Marco, P Franco - ChemEngineering, 2021 - mdpi.com
In this paper, composite systems containing curcumin (CUR) were prepared through
supercritical-assisted atomization (SAA), using different carriers. Curcumin is particularly …