Introduction G protein-coupled receptors (GPCRs) play key roles in many biological
functions and are linked to many diseases across all therapeutic areas. As such, GPCRs …

The lymph node (LN) is an essential tissue for achieving effective immune responses but it is
also critical in the pathogenesis of chronic lymphocytic leukemia (CLL). Within the multitude …

Acute graft-versus-host disease (GVHD) is characterized by severe tissue damage that is a
life-threatening complication of allogeneic hematopoietic stem cell transplantation. Due to …

According to the classical paradigm, CCR7 is a homing chemokine receptor that grants
normal lymphocytes access to secondary lymphoid tissues such as lymph nodes or spleen …

Lymph node (LN) is a key tissue in the pathophysiology of mature blood cancers, especially
for chronic lymphocytic leukemia (CLL). Within the multiple de-regulated pathways affecting …

Graft-versus-host disease (GVHD) is a major complication that occurs following allogeneic
haematopoietic stem cell transplantation (HSCT) for the treatment of haematological cancers …

Graft-versus-host disease (GVHD) is the main complication after allogeneic hematopoietic
stem cell transplantation. We previously unveiled a correlation between proportions of CC …

Background CC chemokine receptor 7 (CCR7) is a member of G-protein-coupled receptor
family and mediates chemotactic migration of immune cells and different cancer cells …

Alloreactivity between donor cells against disparate host tissue is a natural and normal
physiologic phenomenon after engraftment. Consequently, GVHD is a universally expected …