Evaluation of the biological activities of Copaiba (Copaifera spp): a comprehensive review based on scientometric analysis

DR Frazão, JN Cruz, M Santana de Oliveira… - Frontiers in …, 2023 - frontiersin.org
Copaíba oil-resin is extracted from the trunk of the Copaíba tree and has medicinal,
cosmetic, and industrial properties. As a result, widespread knowledge about the use of …

The amide derivative of anticopalic acid induces non-apoptotic cell death in triple-negative breast cancer cells by inhibiting FAK activation

P Chawengrum, N Luepongpatthana, S Thongnest… - Scientific Reports, 2023 - nature.com
Anticopalic acid (ACP), a labdane type diterpenoid obtained from Kaempferia elegans
rhizomes, together with 21 semi-synthetic derivatives, were evaluated for their cancer …

Copalic acid: occurrence, chemistry, and biological activities

VG Medeiros, FJ Durán, KL Lang - Revista Brasileira de Farmacognosia, 2021 - Springer
Copalic acid is a naturally occurring labdane‐type diterpene acid usually isolated from
oleoresins of Copaifera trees, being considered the biomarker for the genus. This compound …

Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: Synthesis and biological evaluation

S Zhang, N Feng, J Huang, M Wang, L Zhang, J Yu… - Bioorganic …, 2020 - Elsevier
Aleuritopteris argentea (SG Gmél.) Fée is a medicinal fern consisting of an ent-labdane
diterpene, ie alepterolic aicd, as the major metabolite. We recently isolated grams of …

Electrospray ionization tandem mass spectrometry of labdane‐type acid diterpenes

GP Aguiar, EJ Crevelin, HJ Dias… - Journal of Mass …, 2018 - Wiley Online Library
Copaifera (Leguminoseae) species produce a commercially interesting oleoresin that
displays several biological activities, including antimicrobial and anti‐inflammatory …

[图书][B] Terpenoids: Chemistry, Biochemistry, Medicinal Effects, Ethno-pharmacology

BK Banik, BM Sahoo, A Tiwari - 2022 - taylorfrancis.com
This unique volume covers specific aspects of the biological chemistry of terpenoids. It
provides extensive information related to classification, general methods of extraction and …

Four diterpenes identified in silico were isolated from Hyptidinae and demonstrated in vitro activity against Mycobacterium tuberculosis

ABS Cavalcanti, MDS Maia… - Natural Product …, 2023 - Taylor & Francis
Abstract Plants of Hyptidinae subtribe (Lamiaceae–family), as Mesosphaerum sidifolium, are
a source of bioactive molecules. In the search for new drug candidates, we perform chemical …

[HTML][HTML] Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug …

ACF Soares, PM Matos, KF Silva… - Journal of the Brazilian …, 2019 - SciELO Brasil
In this work, a search for antimicrobial agents against multi-drug resistant (MDR) bacteria
was undertaken. It involved two natural diterpenes of different basic skeletons, named ent …

Fungal biocatalysts for labdane diterpene hydroxylation

T Cruz de Carvalho, E de Oliveira Silva… - Bioprocess and …, 2020 - Springer
Labdane diterpenes and their derivatives have shown remarkable biological activities and
are useful as chiral building blocks for the synthesis of a variety of bioactive compounds …

In vitro anti-trypanosomal potential of kaurane and pimarane semi-synthetic derivatives

ACFS Rocha, GO Morais, MM da Silva… - Natural Product …, 2022 - Taylor & Francis
As part of the search for anti-trypanosomal agents, this work presents the production of
sixteen derivatives. All of them were obtained from two natural diterpenes, one with kaurane …