The metabolism of polychlorinated biphenyls (PCBs) is complex and has an impact on
toxicity, and thereby on the assessment of PCB risks. A large number of reactive and stable …

Parabens are biocides used as preservatives in food, cosmetics and pharmaceuticals. They
possess antibacterial and antifungal activity due to their ability to disrupt cell membrane and …

Nrf2/ARE pathway plays an important role in adapt to oxidative stress caused by pro-
oxidants and electrophiles through up-regulating phase II detoxifying enzymes. Our previous …

One of the greatest challenges facing the pharmaceutical industry today is the failure of
promising new drug candidates due to unanticipated adverse effects discovered during …

Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …

Comprehensive two-dimensional gas chromatography (GC× GC) offers increased peak
capacity and selectivity relative to conventional one dimensional separations. The analysis …

A group of intracellular nuclear receptors is a protein superfamily including arylhydrocarbon
AhR, estrogen ER, androgen AR, thyroid TR and retinoid receptors RAR/RXR as well as …

Hydroxylated polychlorinated biphenyls (OH-PCBs) are produced in the environment by the
oxidation of PCBs through a variety of mechanisms, including metabolic transformation in …

Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but
their impact on estrogen signaling is still not fully understood. In the present study, we used …

BACKGROUND: Persistent organochlorine pollutants (POP), such as polychlorinated
biphenyls (PCB) and dichlorodiphenyldichloroethylene (p, p′-DDE), are widely found in the …