Processes that are important in cancer progression, such as sustained cell growth, invasion
to other organs, and resistance to cell death inducers, have a clear overlap with pathways …

Breast cancer is one of the most frequent cancer types worldwide and the first cause of
cancer-related deaths in women. Although significant therapeutic advances have been …

Background: Increasing evidence showed that the clinical significance of the interaction
between hypoxia and immune status in tumor microenvironment. However, reliable …

Understanding the cell biological mechanisms that enable tumor cells to persist after therapy
is necessary to improve the treatment of recurrent disease. Here, we demonstrate that …

The tumor microenvironment (TME) is shaped by cancer and noncancerous cells, the
extracellular matrix, soluble factors, and blood vessels. Interactions between the cells …

Background: Colorectal cancer (CRC) is a highly devastating cancer. Ca2+-dependent
channels are now considered key regulators of tumor progression. In this study, we aimed to …

An important component of breast milk, calcium also appears as radiographically prominent
microcalcifications in breast tissue that are often the earliest sign of malignancy. Ionic Ca 2+ …

Simple Summary Cell fate is ultimately determined by the precisely coordinated action of the
Ca2+-signaling machinery. During carcinogenesis, Ca2+ signaling is significantly …

Orai1 plays a major role in store-operated Ca2+ entry (SOCE) in triple-negative breast
cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein …

Orai3 calcium (Ca2+) channels are implicated in multiple breast cancer processes, such as
proliferation and survival as well as resistance to chemotherapy. However, their involvement …