[HTML][HTML] What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
has caused more than 1 million deaths in the first 6 months of the pandemic and huge …
has caused more than 1 million deaths in the first 6 months of the pandemic and huge …
Integrated and patient-centred management of Parkinson's disease: a network model for reshaping chronic neurological care
Chronic neurological diseases are the leading cause of disability globally. Yet, our health-
care systems are not designed to meet the needs of many patients with chronic neurological …
care systems are not designed to meet the needs of many patients with chronic neurological …
Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity
Background: currently one of the major challenges facing clinical guidelines is
multimorbidity. Current guidelines are not designed to consider the cumulative impact of …
multimorbidity. Current guidelines are not designed to consider the cumulative impact of …
Improving representation in clinical trials and research: building research equity for women and underrepresented groups
K Bibbins-Domingo, A Helman - 2022 - pubmed.ncbi.nlm.nih.gov
The United States has long made substantial investments in clinical research with the goal
of improving the health and well-being of our nation. There is no doubt that these …
of improving the health and well-being of our nation. There is no doubt that these …
Rehabilitation to enable recovery from COVID-19: a rapid systematic review
Objectives To establish the evidence for rehabilitation interventions tested in populations of
patients admitted to ICU and critical care with severe respiratory illness, and consider …
patients admitted to ICU and critical care with severe respiratory illness, and consider …
[HTML][HTML] Developing a roadmap to improve trial delivery for under-served groups: results from a UK multi-stakeholder process
Background Participants in clinical research studies often do not reflect the populations for
which healthcare interventions are needed or will be used. Enhancing representation of …
which healthcare interventions are needed or will be used. Enhancing representation of …
Prescribing medicines to older people—How to consider the impact of ageing on human organ and body functions
AC Drenth‐van Maanen, I Wilting… - British journal of …, 2020 - Wiley Online Library
Ageing is associated with several changes in human organs, which result in altered
medication pharmacokinetics and pharmacodynamics. Ageing is also associated with …
medication pharmacokinetics and pharmacodynamics. Ageing is also associated with …
Including older people in health and social care research: best practice recommendations based on the INCLUDE framework
Background Older people are often explicitly or implicitly excluded from research, in
particular clinical trials. This means that study findings may not be applicable to them, or that …
particular clinical trials. This means that study findings may not be applicable to them, or that …
[HTML][HTML] Strategies to improve engagement of 'hard to reach'older people in research on health promotion: a systematic review
Background This systematic review aimed to identify facilitators, barriers and strategies for
engaging 'hard to reach'older people in research on health promotion; the oldest old (≥ 80 …
engaging 'hard to reach'older people in research on health promotion; the oldest old (≥ 80 …
[HTML][HTML] Challenges of conducting research in long-term care facilities: a systematic review
HR Lam, S Chow, K Taylor, R Chow, H Lam, K Bonin… - BMC geriatrics, 2018 - Springer
Background The aim of this review is to describe the challenges and barriers to conducting
research in long-term care facilities. Methods A literature search was conducted in Ovid …
research in long-term care facilities. Methods A literature search was conducted in Ovid …