Liver disease, involving a wide range of liver pathologies from fatty liver, hepatitis, and
fibrosis to cirrhosis and hepatocellular carcinoma, is a serious health problem worldwide. In …

Aging is considered the major risk factor for cancer, one of the most important mortality
causes in the western world. Inflammaging, a state of chronic, low-level systemic …

Hepatocyte cell death during liver injury was classically viewed to occur by either
programmed (apoptosis), or accidental, uncontrolled cell death (necrosis). Growing …

Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of the
metabolic syndrome and its prevalence is rapidly increasing due to its strong association …

Polyphenols are the most abundant antioxidants in the human diet and are widespread
constituents of fruits and beverages, such as tea, coffee, and wine. Epidemiological, clinical …

Proanthocyanidins (PAs) are the most abundant flavonoids in the human diet. Several
epidemiological studies connect PA consumption and health benefits and the designation of …

The insulin signaling pathway is composed of a large number of molecules that positively or
negatively modulate insulin specific signal transduction following its binding to the cognate …

We investigated whether quercetin protects from steatosis and limits the expression of
proinflammatory and fibrogenic genes in C57BL/6J mice with nonalcoholic steatohepatitis …

Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or
excessive energy intake that encompasses the linkage of inflammation, oxidation, and …

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and
ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes …