Roughly 20 years after the discovery of the hepatitis C virus (HCV), and 10 years after the
launch of the current standard of care (SOC) therapy, ie the combination of pegylated …

Viral kinetic (VK) modeling has led to increased understanding of the within host dynamics
of viral infections and the effects of therapy. Here we review recent developments in the …

Data show that viral genotype 1 may increase the risk of cirrhosis and hepatocellular
carcinoma (HCC) compared to genotype 2 in patients with chronic hepatitis C virus (HCV) …

Tissue fibrosis is a core pathologic process that contributes to mortality in~ 45% of the
population and is likely to be influenced by the host genetic architecture. Here we …

Hepatitis C virus (HCV) infection of hepatocytes leads to transcriptional induction of the
chemokine CXCL10, which is considered an interferon (IFN)-stimulated gene. However, we …

Recent genome-wide association studies (GWAS) have identified genetic variations near
the IL28B gene which are strongly associated with spontaneous and treatment-induced …

HCV infection is a global health problem that affects 170 million people worldwide. The
severity of the disease varies from asymptomatic chronic infection to cirrhosis and …

Hepatitis C virus (HCV) is a major cause of chronic viral hepatitis that can lead to cirrhosis
and hepatocellular carcinoma. Only a minority of patients can clear the virus spontaneously …

Systemic levels of interferon‐gamma‐inducible protein‐10 (IP‐10) are predictive of
treatment‐induced clearance in chronic hepatitis C virus (HCV). In the present study, factors …

The analysis of inflammatory cytokines and chemokines produced during hepatitis C virus
(HCV) infection has advanced our understanding of viral‐host interactions and identified …