Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

An update on pharmacotherapy of autism spectrum disorder in children and adolescents

R Goel, JS Hong, RL Findling, NY Ji - International review of …, 2018 - Taylor & Francis
To date, no medication is proven to be effective in treating core symptoms of autism
spectrum disorder (ASD). Psychotropic medications are widely used to target emotional and …

[HTML][HTML] Emerging biomarkers in autism spectrum disorder: a systematic review

RE Frye, S Vassall, G Kaur, C Lewis… - Annals of …, 2019 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) affects approximately 2% of children in the United States
(US) yet its etiology is unclear and effective treatments are lacking. Therapeutic interventions …

Intranasal oxytocin in the treatment of autism spectrum disorders: A multilevel meta-analysis

Y Huang, X Huang, RP Ebstein, R Yu - Neuroscience & Biobehavioral …, 2021 - Elsevier
Intranasal oxytocin has been shown to promote social functioning and has recently been
applied as a treatment for autism spectrum disorders (ASD). The current meta-analysis aims …

Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity

FB Spengler, J Schultz, D Scheele, M Essel, W Maier… - Biological …, 2017 - Elsevier
Background Current neuroimaging perspectives on a variety of mental disorders emphasize
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …

Social skills deficits in autism spectrum disorder: potential biological origins and progress in developing therapeutic agents

RE Frye - CNS drugs, 2018 - Springer
Autism spectrum disorder is defined by two core symptoms: a deficit in social communication
and the presence of repetitive behaviors and/or restricted interests. Currently, there is no US …

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial

H Yamasue, T Okada, T Munesue, M Kuroda… - Molecular …, 2020 - nature.com
Although small-scale studies have described the effects of oxytocin on social deficits in
autism spectrum disorder (ASD), no large-scale study has been conducted. In this …

Nose-to-brain peptide delivery–the potential of nanotechnology

E Samaridou, MJ Alonso - Bioorganic & medicinal chemistry, 2018 - Elsevier
Abstract Nose-to-brain (N-to-B) delivery offers to protein and peptide drugs the possibility to
reach the brain in a non-invasive way. This article is a comprehensive review of the state-of …

Infrequent intranasal oxytocin followed by positive social interaction improves symptoms in autistic children: a pilot randomized clinical trial

J Le, L Zhang, W Zhao, S Zhu, C Lan, J Kou… - Psychotherapy and …, 2022 - karger.com
Introduction: There are currently no approved drug interventions for social behavior
dysfunction in autism spectrum disorder (ASD). Previous trials investigating effects of daily …