Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

5-HT research is now more than 50 years old, and it has generated a wealth of therapeutic
agents, some of which have had a major impact on disease management. The 5-HT …

The mammalian airways are sensitive to inhaled stimuli, and airway diseases are
characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents …

Serotonin, or 5-hydroxytryptamine (5-HT), is a well-known neurotransmitter that plays vital
roles in neural activities and social behaviors. Clinically, deficiency of serotonin is linked …

Abstract The neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) is implicated in
enhancing inflammatory reactions of skin, lung, and gastrointestinal tract. To determine …

Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1
and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of …

Monocytes play a critical role in chronic atopic dermatitis (AD) and are the primary
leukocytes that interact with activated platelets. Although activated platelets release a variety …

Elevated levels of serotonin (5-hydroxytryptamine, 5-HT) are observed in the serum of
asthmatics. Herein, we demonstrate that 5-HT functions independently as an eosinophil …

Pulmonary neuroendocrine cells (PNECs) have been implicated in the development of small
cell lung carcinoma (SCLC) and pediatric asthma, and smoking is a risk factor for both …

The local cytokine environment and presence of stimulatory signals determine whether
monocytes acquire dendritic cell (DC) or macrophage characteristics and functions …