Molecular mechanisms of dietary restriction promoting health and longevity
CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022 - nature.com
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …
extending healthspan and lifespan in diverse species, including rodents and non-human …
The evolving metabolic landscape of chromatin biology and epigenetics
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice
Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …
developing many different age-associated diseases, including cancer, cardiovascular …
[PDF][PDF] Moonlighting functions of metabolic enzymes and metabolites in cancer
The growing field of tumor metabolism has greatly expanded our knowledge of metabolic
reprogramming in cancer. Apart from their established roles, various metabolic enzymes and …
reprogramming in cancer. Apart from their established roles, various metabolic enzymes and …
Targeting the biology of aging with mTOR inhibitors
JB Mannick, DW Lamming - Nature aging, 2023 - nature.com
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
Nuclear metabolism and the regulation of the epigenome
Cellular metabolism has emerged as a major biological node governing cellular behaviour.
Metabolic pathways fuel cellular energy needs, providing basic chemical molecules to …
Metabolic pathways fuel cellular energy needs, providing basic chemical molecules to …
[PDF][PDF] Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation
Ketone bodies are bioactive metabolites that function as energy substrates, signaling
molecules, and regulators of histone modifications. β-hydroxybutyrate (β-OHB) is utilized in …
molecules, and regulators of histone modifications. β-hydroxybutyrate (β-OHB) is utilized in …
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching
VM Schneider, JE Visone, CT Harris… - Proceedings of the …, 2023 - National Acad Sciences
The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …
[HTML][HTML] Interplay among metabolism, epigenetic modifications, and gene expression in cancer
M Huo, J Zhang, W Huang, Y Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Epigenetic modifications and metabolism are two fundamental biological processes. During
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …
tumorigenesis and cancer development both epigenetic and metabolic alterations occur and …