Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …

The growing field of tumor metabolism has greatly expanded our knowledge of metabolic
reprogramming in cancer. Apart from their established roles, various metabolic enzymes and …

Cellular metabolism has emerged as a major biological node governing cellular behaviour.
Metabolic pathways fuel cellular energy needs, providing basic chemical molecules to …

Ketone bodies are bioactive metabolites that function as energy substrates, signaling
molecules, and regulators of histone modifications. β-hydroxybutyrate (β-OHB) is utilized in …

The primary antigenic and virulence determinant of the human malaria parasite Plasmodium
falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are …

The global loss of heterochromatin during ageing has been observed in eukaryotes from
yeast to humans, and this has been proposed as one of the causes of ageing. However, the …