In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

Proteolytic cleavage regulates numerous processes in health and disease. One key player
is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at …

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

Trained immunity describes the capacity of innate immune cells to develop heterologous
memory in response to certain exogenous exposures. This phenomenon mediates, at least …

Purpose: The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma
(PDAC) are poorly understood, posing a major obstacle for the identification of patients …

Background The development of a fast and accurate, non-sputum-based point-of-care triage
test for tuberculosis (TB) would have a major impact on combating the TB burden worldwide …

Cell-autonomous immunity is essential for host organisms to defend themselves against
invasive microbes. In vertebrates, both the adaptive and the innate branches of the immune …

Although CD8+ T cells undergo autonomous clonal proliferation after antigen stimulation in
vivo, the expansion of activated CD4+ T cells is limited by intrinsic factors that are poorly …

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …