[HTML][HTML] Engineered polyketides: Synergy between protein and host level engineering
Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …
compounds often require the utilization of non-native enzymatic machinery that is capable of …
[HTML][HTML] Repurposing modular polyketide synthases and non-ribosomal peptide synthetases for novel chemical biosynthesis
In nature, various enzymes govern diverse biochemical reactions through their specific three-
dimensional structures, which have been harnessed to produce many useful bioactive …
dimensional structures, which have been harnessed to produce many useful bioactive …
Recent advances in re-engineering modular PKS and NRPS assembly lines
C Beck, JFG Garzón, T Weber - Biotechnology and Bioprocess …, 2020 - Springer
Polyketides such as the antibiotic erythromycin or the immunosuppressant rapamycin, and
non-ribosomal peptides, such as the antibiotics penicillin or vancomycin, are important …
non-ribosomal peptides, such as the antibiotics penicillin or vancomycin, are important …
Structural and mechanistic insights into chain release of the polyene PKS thioesterase domain
Y Zhou, W Tao, Z Qi, J Wei, T Shi, Q Kang, J Zheng… - ACS …, 2021 - ACS Publications
Polyketides serve as rich source of therapeutically relevant drug leads. The manipulation of
polyketide synthases (PKSs) for generating derivatives with improved activities usually …
polyketide synthases (PKSs) for generating derivatives with improved activities usually …
Biosynthetic cyclization catalysts for the assembly of peptide and polyketide natural products
ML Adrover‐Castellano, JJ Schmidt… - …, 2021 - Wiley Online Library
Many biologically active natural products are synthesized by nonribosomal peptide
synthetases (NRPSs), polyketide synthases (PKSs) and their hybrids. These …
synthetases (NRPSs), polyketide synthases (PKSs) and their hybrids. These …
[HTML][HTML] Engineering actinomycetes for biosynthesis of macrolactone polyketides
Actinobacteria are characterized as the most prominent producer of natural products (NPs)
with pharmaceutical importance. The production of NPs from these actinobacteria is …
with pharmaceutical importance. The production of NPs from these actinobacteria is …
[HTML][HTML] 大环内酯类抗生素代谢工程的研究进展
郝天怡, 赫卫清 - 生物工程学报, 2021 - cjb.ijournals.cn
14-16 元环的大环内酯类抗生素(Macrolide antibiotics, MA) 是临床上重要的抗感染药物.
随着细菌耐药性的不断增加, 迫切需要研发出新型MA 来应对耐药菌. 通过MA …
随着细菌耐药性的不断增加, 迫切需要研发出新型MA 来应对耐药菌. 通过MA …
[HTML][HTML] Towards precision engineering of canonical polyketide synthase domains: recent advances and future prospects
CL Bayly, VG Yadav - Molecules, 2017 - mdpi.com
Modular polyketide synthases (mPKSs) build functionalized polymeric chains, some of
which have become blockbuster therapeutics. Organized into repeating clusters (modules) …
which have become blockbuster therapeutics. Organized into repeating clusters (modules) …
Diversification of polyketide structures via synthase engineering
T Kornfuehrer, AS Eustáquio - MedChemComm, 2019 - pubs.rsc.org
Polyketide natural products possess diverse biological activities including antibiotic,
anticancer, and immunosuppressive. Their equally varied and complex structures arise from …
anticancer, and immunosuppressive. Their equally varied and complex structures arise from …
[HTML][HTML] Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases
Modular polyketide synthases (PKSs) are a multidomain megasynthase class of biosynthetic
enzymes that have great promise for the development of new compounds, from new …
enzymes that have great promise for the development of new compounds, from new …