Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …

In nature, various enzymes govern diverse biochemical reactions through their specific three-
dimensional structures, which have been harnessed to produce many useful bioactive …

Polyketides such as the antibiotic erythromycin or the immunosuppressant rapamycin, and
non-ribosomal peptides, such as the antibiotics penicillin or vancomycin, are important …

Polyketides serve as rich source of therapeutically relevant drug leads. The manipulation of
polyketide synthases (PKSs) for generating derivatives with improved activities usually …

Many biologically active natural products are synthesized by nonribosomal peptide
synthetases (NRPSs), polyketide synthases (PKSs) and their hybrids. These …

Actinobacteria are characterized as the most prominent producer of natural products (NPs)
with pharmaceutical importance. The production of NPs from these actinobacteria is …

14-16 元环的大环内酯类抗生素(Macrolide antibiotics, MA) 是临床上重要的抗感染药物.
随着细菌耐药性的不断增加, 迫切需要研发出新型MA 来应对耐药菌. 通过MA …

Modular polyketide synthases (mPKSs) build functionalized polymeric chains, some of
which have become blockbuster therapeutics. Organized into repeating clusters (modules) …

Polyketide natural products possess diverse biological activities including antibiotic,
anticancer, and immunosuppressive. Their equally varied and complex structures arise from …

Modular polyketide synthases (PKSs) are a multidomain megasynthase class of biosynthetic
enzymes that have great promise for the development of new compounds, from new …