In contrast to all other organs, liver‐to‐body‐weight ratio needs to be maintained always at
100% of what is required for body homeostasis. Adjustment of liver size to 100% of what is …

The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or
hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while …

The identity of cellular populations that drive liver regeneration after injury is the subject of
intense study, and the contributions of polyploid hepatocytes to organ regeneration and …

A great many cell types are necessary for the myriad capabilities of complex, multicellular
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …

Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and higher) are found in
all mammalian species, but the functional significance of this conserved phenomenon …

Although nearly all mammalian species are diploid, whole-genome duplications occur in
select mammalian tissues as part of normal development. Such programmed …

One of the defining features of the liver is the capacity to maintain a constant size despite
injury. Although the precise molecular signals involved in the maintenance of liver size are …

Liver regeneration is perhaps the most studied example of compensatory growth aimed to
replace loss of tissue in an organ. Hepatocytes, the main functional cells of the liver, manage …

Abstract Three-dimensional (3D) cultures use the property of some cells to self-organize in
matrices and generate structures that can be programmed to represent an organ or a …

Livers are comprised of maturational lineages of cells beginning extrahepatically in the
hepato-pancreatic common duct near the duodenum and intrahepatically in zone 1 by the …