Spinal cord injury (SCI) has considerable impact on patient physical, mental, and financial
health. Secondary SCI is associated with inflammation, vascular destruction, and …

Following spinal cord injury (SCI), a multitude of intrinsic and extrinsic factors adversely
affect the gene programs that govern the expression of regeneration-associated genes …

Nanoplastics with small particle sizes and high surface area/volume ratios easily absorb
environmental pollutants and affect their bioavailability. In this study, polystyrene nanoplastic …

Stem cell transplantation, as a promising treatment for central nervous system (CNS)
diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete …

The microtubule (MT) cytoskeleton of a mature axon is maintained in a stabilized steady
state, yet after axonal injury it can be transformed into a dynamic structure capable of …

Axons of the mammalian CNS lose the ability to regenerate soon after development due to
both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for …

Following peripheral nerve injury, transcriptional responses are orchestrated to regulate the
expression of numerous genes in the lesioned nerve, thus activating the intrinsic …

Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the
degradation of organelles and proteins. It also has a prominent role in modulating aging …

Zebrafish can completely regenerate amputated fins via formation of a blastema, a
proliferative mass of undifferentiated precursor cells. During regenerative growth, blastema …

Functional regeneration after axonal injury requires transected axons to regrow and
reestablish connection with their original target tissue. The spontaneous regenerative …