Data analysis is a very challenging task in LC-MS metabolomic studies. The use of powerful
analytical techniques (eg, high-resolution mass spectrometry) provides high-dimensional …

The advent of proteomics techniques for protein identification (PrI) represented a major step
forward in protein chemistry, 1, 2 and indeed, a legion of laboratories are now using different …

A new denoising and peak picking algorithm (MEND, matched filtration with experimental
noise determination) for analysis of LC− MS data is described. The algorithm minimizes both …

Though MS has always appeared to be quite different from spectroscopy to analytical
chemists who are familiar with both, a careful examination from historical and theoretical …

High-resolution mass spectrometry is widely used in many research fields allowing for
accurate mass determinations. In this context, it is pretty standard that high-resolution profile …

One of the important challenges for MALDI imaging mass spectrometry (MALDI-IMS) is the
unambiguous identification of measured analytes. One way to do this is to match tryptic …

A simple method was developed for the generation of cesium iodide (CsI) cluster ions up to
m/z over 20,000 in matrix-assisted laser desorption/ionization mass spectrometry (MALDI …

High-speed, high-resolution LC separations, using a poly (styrene− divinylbenzene)
monolithic column, have been coupled to MALDI MS and MS/MS through an off-line …

Rationale As a powerful ambient ion source, atmospheric pressure (AP) matrix‐assisted
laser desorption/ionization (MALDI) enables direct analysis at atmospheric …

This paper presents application of sequential enhanced data processing procedures to high-
resolution tandem mass spectra for identification of peptides using the Mascot database …