Temozolomide in the era of precision medicine
A Thomas, M Tanaka, J Trepel, WC Reinhold… - Cancer research, 2017 - AACR
Abstract In the January 1, 2017, issue of Cancer Research, Nagel and colleagues
demonstrate the value of assays that determine the DNA repair capacity of cancers in …
demonstrate the value of assays that determine the DNA repair capacity of cancers in …
The potential roles of p53 signaling reactivation in pancreatic cancer therapy
A Ou, X Zhao, Z Lu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Globally, pancreatic cancer (PC) is a common and highly malignant gastrointestinal tumor
that is characterized by an insidious onset and ready metastasis and recurrence. Over …
that is characterized by an insidious onset and ready metastasis and recurrence. Over …
RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance
S Rao, S Peri, J Hoffmann, KQ Cai, B Harris… - PLoS …, 2019 - journals.plos.org
We have previously demonstrated that loss of the tumor suppressive activity of ribosomal
protein (RP) RPL22 predisposes to development of leukemia in mouse models and …
protein (RP) RPL22 predisposes to development of leukemia in mouse models and …
MGMT expression affects the gemcitabine resistance of pancreatic cancer cells
Y Shi, Y Wang, J Qian, X Yan, Y Han, N Yao, J Ma - Life sciences, 2020 - Elsevier
Pancreatic cancer is a malignant cancer with poor prognosis. This study aimed to explore
how O6-methylguanine-DNA methyltransferase (MGMT) affects the gemcitabine resistance …
how O6-methylguanine-DNA methyltransferase (MGMT) affects the gemcitabine resistance …
Crystal shape engineering of anatase TiO 2 and its biomedical applications
S Yang, N Huang, YM Jin, HQ Zhang, YH Su… - …, 2015 - pubs.rsc.org
As an important metal oxide, titanium dioxide (TiO2), particularly in the anatase phase, has
been extensively investigated and utilized in many technological applications due to its …
been extensively investigated and utilized in many technological applications due to its …
[HTML][HTML] MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ERα and Survivin inhibition …
GC Bobustuc, AB Kassam, RA Rovin, S Jeudy… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The DNA damage repair enzyme, O 6-methylguanine DNA methyltransferase (MGMT) is
overexpressed in breast cancer, correlating directly with estrogen receptor (ER) expression …
overexpressed in breast cancer, correlating directly with estrogen receptor (ER) expression …
DNA mismatch repair gene polymorphisms affect survival in pancreatic cancer
Purpose. DNA mismatch repair (MMR) maintains genomic stability and mediates cellular
response to DNA damage. We aim to demonstrate whether MMR genetic variants affect …
response to DNA damage. We aim to demonstrate whether MMR genetic variants affect …
Effect of DNA repair deficiencies on the cytotoxicity of drugs used in cancer therapy-a review
J Manuel Calderon-Montano… - Current medicinal …, 2014 - ingentaconnect.com
Tumor cells often have defects in DNA repair pathways that make them vulnerable to
specific DNA-damaging anticancer agents. The identification of DNA repair defects in tumor …
specific DNA-damaging anticancer agents. The identification of DNA repair defects in tumor …
Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway
Amyloid beta (Aβ) peptides are related to the pathogenesis of Alzheimer's disease (AD). The
search for therapeutic strategies that lower these peptides has mainly focused on the …
search for therapeutic strategies that lower these peptides has mainly focused on the …
Effect of lomeguatrib–temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells
M Taspinar, S Ilgaz, M Ozdemir, T Ozkan, D Oztuna… - Tumor Biology, 2013 - Springer
Temozolomide (TMZ) is commonly used in the treatment of glioblastoma (GBM). The MGMT
repair enzyme (O 6-methylguanine-DNA methyltransferase) is an important factor causing …
repair enzyme (O 6-methylguanine-DNA methyltransferase) is an important factor causing …